Canadian researchers assessed the relationship between cannabis consumption and fasting insulin levels and insulin resistance in a nationally representative sample of over 129,000 adults. They reported that both current and past cannabis use was associated with significant and persistent changes in insulin levels in obese subjects compared to non-users. However, these changes were only evident in overweight subjects.
“[W]e found that lifetime marijuana use is significantly associated with lower fasting insulin and HOMA-IR (a measure of insulin resistance) in obese individuals,” authors concluded. “We also found that, a long time (> 10 years) after cessation, former users showed significant lower levels of fasting insulin and HOMA-IR scores than did never users, independent of their frequency of use in the past.”